Andy McGuigan was thirty when he signed for Exeter City ahead of the club’s first professional campaign in the Southern League. Having previously appeared for Hibernian and Liverpool, where he had been part of the Division One championship-winning team in 1901, he brought considerable experience when he arrived from the North West of England. Making his bow in Exeter’s first professional game in September 1908 he stayed two seasons before retiring.

After playing junior football in his home town of Newton Stewart, Andy joined Hibernian as a 17-year-old where he stayed for three seasons. He then transferred to Liverpool and helped his new club win the Football league Championship in 1901 by scoring five times in 13 games. Scoring four times against Stoke on 4 January 1902 he eventually brought his Liverpool tally to fourteen goals before moving on to Middlesbrough, Southport Central, Accrington Stanley, Port Vale and Bristol City. 

Andy joined Exeter City in the summer of 1908 and was a member of the Grecians' first-ever professional team that faced Millwall on 2 September 1908 in a Southern League fixture. Netting sixteen times in his first season at St James' Park, he couldn't replicate his form during 1909/10 - when he scored just four times in sixteen outings -and retired from playing at the age of thirty-two.

He then became coach to Bilbao before returning to Liverpool as a scout and later as a director when the club won successive championships in 1922 and 1923.

Andy McGuigan died in Liverpool on 22 August 1948.