Les Afful signed as a trainee with Exeter City after playing for a Merseyside youth team in Toxteth and being brought to Exeter for a friendly by former Birmingham City and Liverpool player Howard Gayle. He also played for Torquay United as well as having several seasons with Truro City.

Les made his first team debut on 17th November 2001 in a 3-0 home FA Cup victory against Cambridge City prior to signing a full professional contract in April 2002. His league debut came on 13th April 2002 in a 0-0 draw away at Leyton Orient. He played fairly regularly in Exeter's first two seasons in the Conference but was out of favour by the time he joined local rivals Torquay United on loan in January 2006. Les played five times for Torquay as they successfully battled against relegation to the Conference but, not being offered terms by either Exeter or Torquay, joined Forest Green Rovers in May 2006.

Les had three seasons at Forest Green during which time he was capped twice by England at non-league level. After Forest Green Les returned to live in Devon and, upon signing for Truro in  June 2009, was to spend eight years with the Cornish club making 277 league appearances and scoring 41 goals. He then joined Taunton Town for the 2017/2018 season and moved to Buckland Athletic the following season. Les retired from football shortly afterwards but continues to live in the South Devon area where he has been involved in various business enterprises over the years.